| Pair Name | Amygdalin, Sorafenib | ||
| Phytochemical Name | Amygdalin (PubChem CID: 656516 ) | ||
| Anticancer drug Name | Sorafenib (PubChem CID: 216239 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Sorafenib |
| Adverse Reactions | Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium; |
| Reference | Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022. ref_link |
| Pair Name | Amygdalin, Sorafenib | |||
| Disease Info | [ICD-11: 2D91] | Ehrlich ascites carcinoma | Investigative | |
| Gene Regulation | Up-regulation | Expression | NFE2L2 | hsa4780 |
| Up-regulation | Expression | SOD1 | hsa6647 | |
| Down-regulation | Expression | MMP9 | hsa4318 | |
| Down-regulation | Expression | VEGFA | hsa7422 | |
| In Vitro Model | EAC-E2G8 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_WJ08 |
| In Vivo Model | Each mouse was injected with 200 mL of 1×10⁶ EAC cells. | |||
| Result | Amy improved the antitumor effect of Sor and had a protective role on liver damage induced by EAC in mice. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Amygdalin potentiates the anti-cancer effect of Sorafenib on Ehrlich ascites carcinoma and ameliorates the associated liver damage. Sci Rep. 2022 Apr 20;12(1):6494. doi: 10.1038/s41598-022-10517-0. | Click |
